Soluciones - Péptidos
Bremelanotida
- Shadiack, A. M., Sharma, S. D., Earle, D. C., Spana, C., & Hallam, T. J. (2007). Melanocortins in the treatment of male and female sexual dysfunction. Current Topics in Medicinal Chemistry, 7(11), 1137–1144. https://doi.org/10.2174/156802607780906681
- Diamond, L. E., Earle, D. C., Garcia, W. D., & Spana, C. (2005). Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology, 65(4), 755–759. https://doi.org/10.1016/j.urology.2004.10.060
- Diamond, L. E., Earle, D. C., Heiman, J. R., Rosen, R. C., Perelman, Michael. A., & Harning, R. (2006). Original research—women’s sexual health: An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT‐141), a melanocortin receptor agonist. The Journal of Sexual Medicine, 3(4), 628–638. https://doi.org/10.1111/j.1743-6109.2006.00268.x
- Molinoff, P. B., Shadiack, A. M., Earle, D., Diamond, L. E., & Quon, C. Y. (2003). Pt-141: A melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences, 994(1), 96–102. https://doi.org/10.1111/j.1749-6632.2003.tb03167.x
- Rosen, R. C., Diamond, L. E., Earle, D. C., Shadiack, A. M., & Molinoff, P. B. (2004). Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra®. International Journal of Impotence Research, 16(2), 135–142. https://doi.org/10.1038/sj.ijir.3901200
GHK-Cu
- Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015). Ghk peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International, 2015, 648108. https://doi.org/10.1155/2015/648108
- Cangul, I. T., Gul, N. Y., Topal, A., & Yilmaz, R. (2006). Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits. Veterinary Dermatology, 17(6), 417–423. https://doi.org/10.1111/j.1365-3164.2006.00551.x
- Downey D., Larrabee W. F., Jr., Voci V., Pickart L. Acceleration of wound healing using glycyl-histidyl-lysine copper (II) Surgical Forum. 1985;25:573–575.
- Ehrlich H. Stimulation of skin healing in immunosuppressed rats. Proceedings of the Symposium on Collagen and Skin Repair; September 1991; Reims, France.
- Miller, T. R., Wagner, J. D., Baack, B. R., & Eisbach, K. J. (2006). Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin. Archives of Facial Plastic Surgery, 8(4), 252–259. https://doi.org/10.1001/archfaci.8.4.252
Gonadorelina
- Labrie, F. (2014). GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer. Endocrine-Related Cancer, 21(4), R301-317. https://doi.org/10.1530/ERC-13-0165
- Secreto, G., Muti, P., Sant, M., Meneghini, E., & Krogh, V. (2017). Medical ovariectomy in menopausal breast cancer patients with high testosterone levels: A further step toward tailored therapy. Endocrine-Related Cancer, 24(11), C21–C29. https://doi.org/10.1530/ERC-17-0251
- Secreto, G., Sieri, S., Agnoli, C., Grioni, S., Muti, P., Zumoff, B., Sant, M., Meneghini, E., & Krogh, V. (2016). A novel approach to breast cancer prevention: Reducing excessive ovarian androgen production in elderly women. Breast Cancer Research and Treatment, 158(3), 553–561. https://doi.org/10.1007/s10549-016-3901-1
- Spicer, D. V., & Pike, M. C. (1994). Sex steroids and breast cancer prevention. Journal of the National Cancer Institute. Monographs, 16, 139–147.
- Vollaard, E. S., van Beek, A. P., Verburg, F. A. J., Roos, A., & Land, J. A. (2011). Gonadotropin-releasing hormone agonist treatment in postmenopausal women with hyperandrogenism of ovarian origin. The Journal of Clinical Endocrinology and Metabolism, 96(5), 1197–1201. https://doi.org/10.1210/jc.2010-1991
NAD+
- Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., Mercken, E. M., Palmeira, C. M., de Cabo, R., Rolo, A. P., Turner, N., Bell, E. L., & Sinclair, D. A. (2013). Declining nad+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624–1638. https://doi.org/10.1016/j.cell.2013.11.037
- Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464–471. https://doi.org/10.1016/j.tcb.2014.04.002
- Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998). Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proceedings of the National Academy of Sciences of the United States of America, 95(15), 8892–8897. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21173/
- Mendelsohn, A. R., & Larrick, J. W. (2014). Partial reversal of skeletal muscle aging by restoration of normal NAD+ levels. Rejuvenation Research, 17(1), 62–69. https://doi.org/10.1089/rej.2014.1546
- Sun, N., Youle, R. J., & Finkel, T. (2016). The mitochondrial basis of aging. Molecular Cell, 61(5), 654–666. https://doi.org/10.1016/j.molcel.2016.01.028
Oxytocina
- Gouin, J.-P., Carter, C. S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W. B., Loving, T. J., Stowell, J., & Kiecolt-Glaser, J. K. (2010). Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology, 35(7), 1082–1090. https://doi.org/10.1016/j.psyneuen.2010.01.009
- Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62(12), 1377–1384. https://doi.org/10.1001/archpsyc.62.12.1377
- Reiss, A. B., Glass, D. S., Lam, E., Glass, A. D., De Leon, J., & Kasselman, L. J. (2019). Oxytocin: Potential to mitigate cardiovascular risk. Peptides, 117, 170089. https://doi.org/10.1016/j.peptides.2019.05.001
- Wang, P., Wang, S. C., Yang, H., Lv, C., Jia, S., Liu, X., Wang, X., Meng, D., Qin, D., Zhu, H., & Wang, Y.-F. (2019). Therapeutic potential of oxytocin in atherosclerotic cardiovascular disease: Mechanisms and signaling pathways. Frontiers in Neuroscience, 13. https://doi.org/10.3389/fnins.2019.00454
- Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., Lesch, K.-P., Heindel, W., Kirschbaum, C., Arolt, V., Gerlach, A. L., Hoyer, J., Deckert, J., Zwanzger, P., & Domschke, K. (2015). Oxytocin receptor gene methylation: Converging multilevel evidence for a role in social anxiety. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 40(6), 1528–1538. https://doi.org/10.1038/npp.2015.2
Semaglutida
- Blonde, L., Klein, E. J., Han, J., Zhang, B., Mac, S. M., Poon, T. H., Taylor, K. L., Trautmann, M. E., Kim, D. D., & Kendall, D. M. (2006). Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes, Obesity & Metabolism, 8(4), 436–447. https://doi.org/10.1111/j.1463-1326.2006.00602.x
- Gibbons, C., Blundell, J., Tetens Hoff, S., Dahl, K., Bauer, R., & Bækdal, T. (2021). Effects of oral semaglutide on energy intake, food preference, appetite, control of eating and body weight in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism, 23(2), 581–588. https://doi.org/10.1111/dom.14255
- Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., Lingvay, I., Rosenstock, J., Seufert, J., Warren, M. L., Woo, V., Hansen, O., Holst, A. G., Pettersson, J., & Vilsbøll, T. (2016). Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. New England Journal of Medicine, 375(19), 1834–1844. https://doi.org/10.1056/NEJMoa1607141
- Rubino, D., Abrahamsson, N., Davies, M., Hesse, D., Greenway, F. L., Jensen, C., Lingvay, I., Mosenzon, O., Rosenstock, J., Rubio, M. A., Rudofsky, G., Tadayon, S., Wadden, T. A., Dicker, D., STEP 4 Investigators, Friberg, M., Sjödin, A., Dicker, D., Segal, G., … Warren, M. L. (2021). Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: The step 4 randomized clinical trial. JAMA, 325(14), 1414. https://doi.org/10.1001/jama.2021.3224
- Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T. D., Wadden, T. A., Wharton, S., Yokote, K., Zeuthen, N., & Kushner, R. F. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183
Sermorelina
- Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., Wang, B., Premer, C., Balkan, W., Rodriguez, J., Valdes, D., Rosado, M., Block, N. L., Goldstein, P., Morales, A., Cai, R., Sha, W., Schally, A. V., & Hare, J. M. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 4(4), e001464. https://doi.org/10.1161/JAHA.114.001464
- Kanashiro-Takeuchi, R. M., Szalontay, L., Schally, A. V., Takeuchi, L. M., Popovics, P., Jaszberenyi, M., Vidaurre, I., Zarandi, M., Cai, R.-Z., Block, N. L., Hare, J. M., & Rick, F. G. (2015). New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget, 6(12), 9728–9739. https://doi.org/10.18632/oncotarget.3303
- Shepherd, B. S., Johnson, J. K., Silverstein, J. T., Parhar, I. S., Vijayan, M. M., McGuire, A., & Weber, G. M. (2007). Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 146(3), 390–399. https://doi.org/10.1016/j.cbpa.2006.11.004
- Wahid, S. T., Marbach, P., Stolz, B., Miller, M., James, R. A., & Ball, S. G. (2002). Partial tachyphylaxis to somatostatin (Sst) analogues in a patient with acromegaly: The role of SST receptor desensitisation and circulating antibodies to SST analogues. European Journal of Endocrinology, 146(3), 295–302. https://doi.org/10.1530/eje.0.1460295
- Walker, R. F. (2006). Sermorelin: A better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging, 1(4), 307–308. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699646/